The Science and Business of Biotechnology

<div class="xblock xblock-public_view xblock-public_view-vertical" data-has-score="False" data-block-type="vertical" data-request-token="95c19bd884be11ef87a412578eed8dbf" data-usage-id="block-v1:MITx+15.480x+3T2021+type@vertical+block@217589399dd841188f5b22782031b522" data-init="VerticalStudentView" data-runtime-class="LmsRuntime" data-runtime-version="1" data-graded="False" data-course-id="course-v1:MITx+15.480x+3T2021"> <h2 class="hd hd-2 unit-title">Syllabus and Course Schedule</h2> <div class="vert-mod"> <div class="vert vert-0" data-id="block-v1:MITx+15.480x+3T2021+type@html+block@b0ea88bb21974d36b5aeab87f4797d80"> <div class="xblock xblock-public_view xblock-public_view-html xmodule_display xmodule_HtmlBlock" data-has-score="False" data-block-type="html" data-request-token="95c19bd884be11ef87a412578eed8dbf" data-usage-id="block-v1:MITx+15.480x+3T2021+type@html+block@b0ea88bb21974d36b5aeab87f4797d80" data-init="XBlockToXModuleShim" data-runtime-class="LmsRuntime" data-runtime-version="1" data-graded="False" data-course-id="course-v1:MITx+15.480x+3T2021"> <script type="json/xblock-args" class="xblock-json-init-args"> {"xmodule-type": "HTMLModule"} </script> Week 0: <ul> <ul> <ul> <ul> <li>Syllabus and Calendar</li> <li>Homework, Discussion, and Collaboration Guidelines</li> </ul> </ul> </ul> </ul> Unit 0a: Introduction to Healthcare Finance <ul> <ul> <ul> <ul> <li>Lecture: Current Challenges in Healthcare Finance</li> <li>Lecture: Biomedical Megafund FAQs</li> </ul> </ul> </ul> </ul> Unit 0b: Introduction to the Science of Biotechnology <ul style="padding-left: 30px;"> <ul> <ul> <li>Lecture: Drug Development</li> <li>Biology Background Slides</li> </ul> </ul> </ul> Week 1: Unit 1a: Therapeutic Recombinant Proteins <ul style="padding-left: 30px;"> <ul> <ul> <li>Lecture: Recombinant Therapeutic Proteins</li> <li>Problem Set 1a</li> </ul> </ul> </ul> Unit 1b: Present Value <ul> <ul> <ul> <ul> <li>Lecture: Market Efficiency, the Wisdom of Crowds, and the Madness of Mobs</li> <li>Lecture: Time Value of Money and Drug Pricing Examples</li> <li>Lecture: Buying Cures vs. Renting Health</li> <li>Lecture: Inflation</li> <li>Solved Practice Problems</li> <li>Problem Set 1b</li> </ul> </ul> </ul> </ul> Week 2: Unit 2a: AAV Vectors & In Vivo Gene Therapy <ul> <ul> <ul> <ul> <li>Lecture: Adeno Associated Viral (AAV) Vectors</li> <li>Lecture: In Vivo Gene Therapy</li> <li>Problem Set 2a</li> </ul> </ul> </ul> </ul> Unit 2b: Capital Budgeting <ul style="padding-left: 30px;"> <ul> <ul> <li>Lecture: Cash Flows, NPV, and IRR</li> <li>Lecture: Genetech and Herceptin Funding Example</li> <li>Solved Practice Problems</li> <li>Problem Set 2b</li> </ul> </ul> </ul> Week 3: Unit 3a: Ex-Vivo Gene Therapy <ul> <ul> <ul> <ul> <li>Lecture: Retroviral & Lentiviral Vectors</li> <li>Lecture: Application to Two Major Red Cell Disorders</li> <li>Problem Set 3a</li> </ul> </ul> </ul> </ul> Unit 3b: Stocks and Bonds <ul style="padding-left: 30px;"> <ul> <ul> <li>Lecture: Stocks and Bonds</li> <li>Solved Practice Problems</li> <li>Problem Set 3b</li> </ul> </ul> </ul> Week 4: Unit 4a: Nucleic Acid Therapies <ul> <ul> <ul> <ul> <li>Lecture: Oligonucleotides Affecting Splicing of pre-mRNA</li> <li>Lecture: shRNAs Causing Degradation of Target mRNAs</li> <li>Problem Set 4a</li> </ul> </ul> </ul> </ul> Unit 4b: The CAPM & Diversification <ul style="padding-left: 30px;"> <ul> <ul> <li>Lecture: Volatility, Risk and Uncertainty</li> <li>Lecture: The CAPM</li> <li>Lecture: Portfolio Theory</li> <li>Lecture: Portfolio Theory in a Biomedical Context</li> <li>Solved Practice Problems</li> <li>Problem Set 4b</li> </ul> </ul> </ul> Week 5: Unit 5a: Gene Editing <ul> <ul> <ul> <ul> <li>Lecture: ZFNs and TALENs</li> <li>Lecture: CRISPR</li> <li>Problem Set 5a</li> </ul> </ul> </ul> </ul> Unit 5b: Options <ul style="padding-left: 30px;"> <ul> <ul> <li>Lecture: Option Pricing Theory</li> <li>Lecture: Real Options and Biomedical Examples</li> <li>Lecture: Monte Carlo Simulations</li> <li>Solved Practice Problems</li> <li>Problem Set 5b</li> </ul> </ul> </ul> Week 6: Unit 6: Clinical Trials <ul> <ul> <ul> <ul> <li>Lecture: Drug Development & Clinical Trials</li> <li>Lecture: Statistical Framework for Clinical Trials</li> <li>Lecture: Bayesian Adaptive Clinical Trials</li> <li>Problem Set 6</li> </ul> </ul> </ul> </ul> Week 7: Unit 7a: Antibody Generation <ul> <ul> <ul> <ul> <li>Lecture: Vaccines, Antibodies, and Antibody Generation</li> <li>Problem Set 7a</li> </ul> </ul> </ul> </ul> Unit 7b: Venture Capital & New Business Models <ul style="padding-left: 30px;"> <ul> <ul> <li>Lecture: Financing a Start-Up</li> <li>Lecture: Valuation</li> <li>Problem Set 7b</li> </ul> </ul> </ul> Week 8: Unit 8a: Monoclonal Antibodies <ul> <ul> <ul> <ul> <li>Lecture: Monoclonal Antibodies</li> <li>Problem Set 8a</li> </ul> </ul> </ul> </ul> Unit 8b: Securitization <ul style="padding-left: 30px;"> <ul> <ul> <li>Lecture: The Financial Crisis & Securitization</li> <li>Lecture: Megafunds & Their Limits</li> <li>Problem Set 8b</li> </ul> </ul> </ul> Week 9: Unit 9a: Cancer Immunotherapeutics <ul> <ul> <ul> <ul> <li>Lecture: Immunotherapeutics for Cancers</li> <li>Problem Set 9a</li> </ul> </ul> </ul> </ul> Unit 9b: Healthcare Analytics <ul style="padding-left: 30px;"> <ul> <ul> <li>Lecture: Risk and Return in the Biopharma Industries</li> <li>Lecture: Clinical Trial Success Rates</li> <li>Lecture: Predictive Analytics for Drug Approvals and Clinical-Phase Transitions</li> <li>Lecture: Bayesian Decision Analysis for Randomized Clinical Trials</li> <li>Problem Set 9b</li> </ul> </ul> </ul> Week 10: Unit 10a: New Cell Therapies <ul> <ul> <ul> <ul> <li>Lecture: ES Cells & iPS Cells</li> <li>Lecture: Engineered Red Blood Cells (Rubius)</li> <li>Problem Set 10a</li> </ul> </ul> </ul> </ul> Unit 10b: Pricing, Value, and Ethics <ul style="padding-left: 30px;"> <ul> <ul> <li>Lecture: Pricing, Value, and Ethics</li> <li>Lecture: Pricing Issues</li> <li>Lecture: Value vs Price</li> </ul> </ul> </ul> Final Exam <ul> <ul> <ul> <li>Final Exam (Released March 1st, to be completed at your own pace!)</li> </ul> </ul> </ul> </div> </div> </div> </div>