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<h2 class="hd hd-2 unit-title">Lecture 4.2</h2>
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<h3 class="hd hd-2">Lecture 4.2</h3>
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<p><b>Correction:</b> On the slide that appears at 7:07...</p>
<ol><ol>
<li>The second DNA sequence (the sequence with the underlined point mutation) should read 3' at the end.</li>
<li>The second template (containing the point mutation) should read <b>5' TACAGCGAGGACCA<span style="text-decoration: underline;">A</span>ATT 3'</b>.</li>
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<h2 class="hd hd-2 unit-title">Reference Summary</h2>
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<h3><b> Alleles </b></h3>
<p>An <b>allele</b> is a version of a gene that determines which trait will be expressed. This occurs because each allele encodes slightly different versions of the same protein product.</p>
<h3><b> Segregation of Alleles </b></h3>
<p> In <b>mitosis</b>, each daughter cell will end up with the same alleles as the original mother cell. <br /> Therefore, if the mother cell possesses alleles B and b for gene 1, then both daughters will have both B AND b. </p>
<p> However, in <b>meiosis</b>, each gamete produced will have only one allele of each gene from the mother cell.<br /> Therefore, if the mother cell possesses alleles D and d for gene 2, then each gamete will have either D OR d. <br /> Which allele a gamete will inherit for one gene is <b>independent</b> of which allele it will inherit for another gene. This means that all of the allelic combinations shown in the diagram below are equally likely to arise in the gametes from the mother cell. </p>
<img src='/assets/courseware/v1/3445c2e1f1b9942a7ea2967ea43b4373/asset-v1:OCW+Pre-7.01+1T2020+type@asset+block/r0.png' alt="This diagram depicts a cell that undergoes meiosis. The cell has two pairs of homologous chromosomes, each with one gene, undergoing meiosis. Each gene has two alleles. One chromosome carries a gene with alleles big B or small b. The other chromosome carries a gene with alleles big H or small h. The parent cell is diploid and has a genotype of big B small b and big H small h.
First, there is a cell, represented as a circle, that has two chromosomes. These chromosomes are each represented as a line in the cell. One chromosome is labelled A 1 and the other is labeled A 2. Then, an arrow labelled D N A replication points from this first cell diagram to a second cell diagram. This second circle contains four lines that represent the two copies of the two original chromosomes. The two lines labelled A 1 are paired and the other two lines labelled A 2 are paired. There are two arrows that stem from the second cell diagram, and each one points to a new cell to indicate that the original cell has divide into two new cells. In this step, known as Meiosis I, the homologous chromosomes separate. Therefore, one of these new cells contains the two paired A 1 chromosomes and the other new cell contains the two paired A 2 chromosomes. The next step is labelled Meiosis II and is when sister chromatids separate. Each of the two cells produced from Meiosis I divides to produce two new cells. Each of these new cells contains one copy of one chromosome. Therefore, a total of four cells are produced. Two of these product cells have a single copy of the A 1 chromosome, and two of these product cells have a single copy of the A 2 chromosome. Thus, the products of meiosis are 4 haploid gametes.">
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<h2 class="hd hd-2 unit-title">Exercise 1 (Meiosis)</h2>
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Question 1
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<p>Below is a cell undergoing meiosis with two pairs of chromosomes and two alleles of each of the apple (A, a) and honey (H, h) genes.</p>
<p><img src="/assets/courseware/v1/14dc00bf1952499a87ba9905fdcf6132/asset-v1:OCW+Pre-7.01+1T2020+type@asset+block/4.2_ex1.png" width="700" style="float:center;" alt="A diagram of circles representing cells at various stages of meiosis. The parent cell starts with 2 genes (A and H) that each have two alleles. The parent undergoes replication then undergoes meiosis 1. After meiosis 1, four cells are created: A small h, A H, small a H, and small a small h. Products after meiosis 2 are left blank for the question."/> </p>
<p>Use the dropdown options to indicate the genotype of the gametes.</p>
<ul>
<li>Gamete #1 contains:<div class="inline" tabindex="-1" aria-label="Question 1" role="group"><div class="inputtype option-input inline">
<select name="input_526d2a253e3049b79c171110de197ca5_2_1" id="input_526d2a253e3049b79c171110de197ca5_2_1" aria-describedby="status_526d2a253e3049b79c171110de197ca5_2_1">
<option value="option_526d2a253e3049b79c171110de197ca5_2_1_dummy_default">Select an option</option>
<option value="one (1) A"> one (1) A</option>
<option value="one (1) a"> one (1) a</option>
<option value="two (2) A"> two (2) A</option>
<option value="two (2) a"> two (2) a</option>
<option value="no A or a"> no A or a</option>
</select>
<div class="indicator-container">
<span class="status unanswered" id="status_526d2a253e3049b79c171110de197ca5_2_1" data-tooltip="Not yet answered.">
<span class="sr">unanswered</span><span class="status-icon" aria-hidden="true"/>
</span>
</div>
<p class="answer" id="answer_526d2a253e3049b79c171110de197ca5_2_1"/>
</div></div><b>AND</b><div class="inline" tabindex="-1" aria-label="Question 2" role="group"><div class="inputtype option-input inline">
<select name="input_526d2a253e3049b79c171110de197ca5_3_1" id="input_526d2a253e3049b79c171110de197ca5_3_1" aria-describedby="status_526d2a253e3049b79c171110de197ca5_3_1">
<option value="option_526d2a253e3049b79c171110de197ca5_3_1_dummy_default">Select an option</option>
<option value="one (1) H"> one (1) H</option>
<option value="one (1) h"> one (1) h</option>
<option value="two (2) H"> two (2) H</option>
<option value="two (2) h"> two (2) h</option>
<option value="no H or h"> no H or h</option>
</select>
<div class="indicator-container">
<span class="status unanswered" id="status_526d2a253e3049b79c171110de197ca5_3_1" data-tooltip="Not yet answered.">
<span class="sr">unanswered</span><span class="status-icon" aria-hidden="true"/>
</span>
</div>
<p class="answer" id="answer_526d2a253e3049b79c171110de197ca5_3_1"/>
</div></div></li>
<li>Gamete #2 contains:<div class="inline" tabindex="-1" aria-label="Question 3" role="group"><div class="inputtype option-input inline">
<select name="input_526d2a253e3049b79c171110de197ca5_4_1" id="input_526d2a253e3049b79c171110de197ca5_4_1" aria-describedby="status_526d2a253e3049b79c171110de197ca5_4_1">
<option value="option_526d2a253e3049b79c171110de197ca5_4_1_dummy_default">Select an option</option>
<option value="one (1) A"> one (1) A</option>
<option value="one (1) a"> one (1) a</option>
<option value="two (2) A"> two (2) A</option>
<option value="two (2) a"> two (2) a</option>
<option value="no A or a"> no A or a</option>
</select>
<div class="indicator-container">
<span class="status unanswered" id="status_526d2a253e3049b79c171110de197ca5_4_1" data-tooltip="Not yet answered.">
<span class="sr">unanswered</span><span class="status-icon" aria-hidden="true"/>
</span>
</div>
<p class="answer" id="answer_526d2a253e3049b79c171110de197ca5_4_1"/>
</div></div><b>AND</b><div class="inline" tabindex="-1" aria-label="Question 4" role="group"><div class="inputtype option-input inline">
<select name="input_526d2a253e3049b79c171110de197ca5_5_1" id="input_526d2a253e3049b79c171110de197ca5_5_1" aria-describedby="status_526d2a253e3049b79c171110de197ca5_5_1">
<option value="option_526d2a253e3049b79c171110de197ca5_5_1_dummy_default">Select an option</option>
<option value="one (1) H"> one (1) H</option>
<option value="one (1) h"> one (1) h</option>
<option value="two (2) H"> two (2) H</option>
<option value="two (2) h"> two (2) h</option>
<option value="no H or h"> no H or h</option>
</select>
<div class="indicator-container">
<span class="status unanswered" id="status_526d2a253e3049b79c171110de197ca5_5_1" data-tooltip="Not yet answered.">
<span class="sr">unanswered</span><span class="status-icon" aria-hidden="true"/>
</span>
</div>
<p class="answer" id="answer_526d2a253e3049b79c171110de197ca5_5_1"/>
</div></div></li>
<li>Gamete #3 contains:<div class="inline" tabindex="-1" aria-label="Question 5" role="group"><div class="inputtype option-input inline">
<select name="input_526d2a253e3049b79c171110de197ca5_6_1" id="input_526d2a253e3049b79c171110de197ca5_6_1" aria-describedby="status_526d2a253e3049b79c171110de197ca5_6_1">
<option value="option_526d2a253e3049b79c171110de197ca5_6_1_dummy_default">Select an option</option>
<option value="one (1) A"> one (1) A</option>
<option value="one (1) a"> one (1) a</option>
<option value="two (2) A"> two (2) A</option>
<option value="two (2) a"> two (2) a</option>
<option value="no A or a"> no A or a</option>
</select>
<div class="indicator-container">
<span class="status unanswered" id="status_526d2a253e3049b79c171110de197ca5_6_1" data-tooltip="Not yet answered.">
<span class="sr">unanswered</span><span class="status-icon" aria-hidden="true"/>
</span>
</div>
<p class="answer" id="answer_526d2a253e3049b79c171110de197ca5_6_1"/>
</div></div><b>AND</b><div class="inline" tabindex="-1" aria-label="Question 6" role="group"><div class="inputtype option-input inline">
<select name="input_526d2a253e3049b79c171110de197ca5_7_1" id="input_526d2a253e3049b79c171110de197ca5_7_1" aria-describedby="status_526d2a253e3049b79c171110de197ca5_7_1">
<option value="option_526d2a253e3049b79c171110de197ca5_7_1_dummy_default">Select an option</option>
<option value="one (1) H"> one (1) H</option>
<option value="one (1) h"> one (1) h</option>
<option value="two (2) H"> two (2) H</option>
<option value="two (2) h"> two (2) h</option>
<option value="no H or h"> no H or h</option>
</select>
<div class="indicator-container">
<span class="status unanswered" id="status_526d2a253e3049b79c171110de197ca5_7_1" data-tooltip="Not yet answered.">
<span class="sr">unanswered</span><span class="status-icon" aria-hidden="true"/>
</span>
</div>
<p class="answer" id="answer_526d2a253e3049b79c171110de197ca5_7_1"/>
</div></div></li>
<li>Gamete #4 contains:<div class="inline" tabindex="-1" aria-label="Question 7" role="group"><div class="inputtype option-input inline">
<select name="input_526d2a253e3049b79c171110de197ca5_8_1" id="input_526d2a253e3049b79c171110de197ca5_8_1" aria-describedby="status_526d2a253e3049b79c171110de197ca5_8_1">
<option value="option_526d2a253e3049b79c171110de197ca5_8_1_dummy_default">Select an option</option>
<option value="one (1) A"> one (1) A</option>
<option value="one (1) a"> one (1) a</option>
<option value="two (2) A"> two (2) A</option>
<option value="two (2) a"> two (2) a</option>
<option value="no A or a"> no A or a</option>
</select>
<div class="indicator-container">
<span class="status unanswered" id="status_526d2a253e3049b79c171110de197ca5_8_1" data-tooltip="Not yet answered.">
<span class="sr">unanswered</span><span class="status-icon" aria-hidden="true"/>
</span>
</div>
<p class="answer" id="answer_526d2a253e3049b79c171110de197ca5_8_1"/>
</div></div><b>AND</b><div class="inline" tabindex="-1" aria-label="Question 8" role="group"><div class="inputtype option-input inline">
<select name="input_526d2a253e3049b79c171110de197ca5_9_1" id="input_526d2a253e3049b79c171110de197ca5_9_1" aria-describedby="status_526d2a253e3049b79c171110de197ca5_9_1">
<option value="option_526d2a253e3049b79c171110de197ca5_9_1_dummy_default">Select an option</option>
<option value="one (1) H"> one (1) H</option>
<option value="one (1) h"> one (1) h</option>
<option value="two (2) H"> two (2) H</option>
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