The Science and Business of Biotechnology

1. Syllabus and Course Schedule
2. Homework and Collaboration Guidelines
1. Unit Overview and Handouts
2. Lecture: Current Challenges in Healthcare Finance
3. Lecture: Biomedical Megafund FAQs
1. Unit Overview and Handouts
2. Lecture: Drug Development
3. Biology Background Slides
1. Unit Overview and Handouts
2. Lecture: Recombinant Therapeutic Proteins
1. Unit Overview and Handouts
2. Lecture: Market Efficiency, the Wisdom of Crowds, and the Madness of Mobs
3. Lecture: The Time Value of Money and Drug Pricing Examples
4. Lecture: Buying Cures vs. Renting Health
5. Lecture: Inflation
6. Solved Practice Problems
1. Unit Overview and Handouts
2. Lecture: Adeno Associated Viral (AAV) Vectors
3. Lecture: In Vivo Gene Therapy
1. Unit Overview and Handouts
2. Lecture: Cash Flows, NPV, and IRR
3. Lecture: Genetech and Herceptin Funding Example
4. Solved Practice Problems
1. Unit Overview and Handouts
2. Lecture: Retroviral & Lentiviral Vectors
3. Lecture: Application to Two Major Red Cell Disorders
4. Additional Material: Guest Speakers
1. Unit Overview and Handouts
2. Lecture: Stocks and Bonds
3. Solved Practice Problems
1. Unit Overview and Handouts
2. Lecture: Oligonucleotides Affecting Splicing of pre-mRNA
3. Lecture: shRNAs Causing Degradation of Target mRNAs
1. Unit Overview and Handouts
2. Lecture: Volatility, Risk, and Uncertainty
3. Lecture: The CAPM
4. Lecture: Portfolio Theory
5. Lecture: Portfolio Theory in a Biomedical Context
6. Solved Practice Problems
1. Unit Overview and Handouts
2. Lecture: ZFNs and TALENs
3. Lecture: CRISPR
4. Additional Material: Guest Speakers
1. Unit Overview and Handouts
2. Lecture: Option Pricing Theory
3. Lecture: Real Options and Biomedical Examples
4. Lecture: Monte Carlo Simulations
5. Solved Practice Problems
1. Unit Overview and Handouts
2. Lecture: Drug Development & Clinical Trials
3. Lecture: Statistical Framework for Clinical Trials
4. Lecture: Bayesian Adaptive Clinical Trials
5. Additional Material: Guest Speakers
1. Unit Overview and Handouts
2. Lecture: Vaccines, Antibodies, and Antibody Generation
3. Additional Material: Guest Speakers
1. Unit Overview and Handouts
2. Lecture: Financing a Start-Up
3. Additional Material: Guest Speakers
1. Unit Overview and Handouts
2. Lecture: Monoclonal Antibodies
1. Unit Overview and Handouts
2. Lecture: The Financial Crisis & Securitization
3. Lecture: Megafunds & Their Limits
4. Additional Material: Guest Speakers
1. Unit Overview and Handouts
2. Lecture: Immunotherapeutics for Cancers
1. Unit Overview and Handouts
2. Lecture: Risk and Return in the Biopharma Industries
3. Lecture: Clinical Trial Success Rates
4. Lecture: Predictive Analytics for Drug Approvals and Clinical-Phase Transitions
5. Lecture: Bayesian Decision Analysis for Randomized Clinical Trials
6. Additional Material: Guest Speakers
1. Unit Overview and Handouts
2. Lecture: ES Cells & iPS Cells
3. Lecture: Engineered Red Blood Cells (Rubius)
1. Unit Overview and Handouts
2. Lecture: Pricing, Value, and Ethics
3. Lecture: Pricing Issues
4. Lecture: Value vs Price
5. Additional Material: Guest Speakers
1. Interviews
1. Conclusion and Acknowledgments

Welcome to 15.480x!

Syllabus and Course Schedule

Homework and Collaboration Guidelines

Unit 0a: Introduction to Healthcare Finance

Unit Overview and Handouts

Lecture: Current Challenges in Healthcare Finance

Lecture: Biomedical Megafund FAQs

Unit 0b: Introduction to the Science of Biotechnology

Unit Overview and Handouts

Lecture: Drug Development

Biology Background Slides

Unit 1a: Therapeutic Recombinant Proteins

Unit Overview and Handouts

Lecture: Recombinant Therapeutic Proteins

Unit 1b: Present Value

Unit Overview and Handouts

Lecture: Market Efficiency, the Wisdom of Crowds, and the Madness of Mobs

Lecture: The Time Value of Money and Drug Pricing Examples

Lecture: Buying Cures vs. Renting Health

Lecture: Inflation

Solved Practice Problems

Unit 2a: AAV Vectors & In Vivo Gene Therapy

Unit Overview and Handouts

Lecture: Adeno Associated Viral (AAV) Vectors

Lecture: In Vivo Gene Therapy

Unit 2b: Capital Budgeting

Unit Overview and Handouts

Lecture: Cash Flows, NPV, and IRR

Lecture: Genetech and Herceptin Funding Example

Solved Practice Problems

Unit 3a: Ex Vivo Gene Therapy

Unit Overview and Handouts

Lecture: Retroviral & Lentiviral Vectors

Lecture: Application to Two Major Red Cell Disorders

Additional Material: Guest Speakers

Unit 3b: Stocks and Bonds

Unit Overview and Handouts

Lecture: Stocks and Bonds

Solved Practice Problems

Unit 4a: Nucleic Acid Therapies

Unit Overview and Handouts

Lecture: Oligonucleotides Affecting Splicing of pre-mRNA

Lecture: shRNAs Causing Degradation of Target mRNAs

Unit 4b: The CAPM & Diversification

Unit Overview and Handouts

Lecture: Volatility, Risk, and Uncertainty

Lecture: The CAPM

Lecture: Portfolio Theory

Lecture: Portfolio Theory in a Biomedical Context

Solved Practice Problems

Unit 5a: Gene Editing

Unit Overview and Handouts

Lecture: ZFNs and TALENs

Lecture: CRISPR

Additional Material: Guest Speakers

Unit 5b: Options

Unit Overview and Handouts

Lecture: Option Pricing Theory

Lecture: Real Options and Biomedical Examples

Lecture: Monte Carlo Simulations

Solved Practice Problems

Unit 6: Clinical Trials

Unit Overview and Handouts

Lecture: Drug Development & Clinical Trials

Lecture: Statistical Framework for Clinical Trials

Lecture: Bayesian Adaptive Clinical Trials

Additional Material: Guest Speakers

Unit 7a: Antibody Generation

Unit Overview and Handouts

Lecture: Vaccines, Antibodies, and Antibody Generation

Additional Material: Guest Speakers

Unit 7b: Venture Capital & New Business Models

Unit Overview and Handouts

Lecture: Financing a Start-Up

Additional Material: Guest Speakers

Unit 8a: Monoclonal Antibodies

Unit Overview and Handouts

Lecture: Monoclonal Antibodies

Unit 8b: Securitization

Unit Overview and Handouts